Ongoing osteomalacia can result in pain, limitations in range of motion, and even disability

Measurements showing pain, stiffness, and physical function in adults

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a questionnaire designed to assess pain, stiffness, and physical function in patients with hip and/or knee osteoarthritis. It has been used among patients with different conditions, including low back pain, rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia.1


Experience of pain may be exacerbated by the development of painful extraosseous calcifications (spine, neck, Achilles, hips) and osteoarthritis.2 Adults with XLH reported increased pain and stiffness.2

The data is taken from an international burden-of-disease study conducted in 232 adult patients with XLH.2

About 50% of adults that have low-trauma fracture

On average, approximately 44% of adults with XLH indicated a history of fractures. The mean age at first fracture was 26.4 years. The average age of adults reporting fractures was 48.4 years and 42% reported at least three fractures.2

Survey showing limitations in range of motion and impairment in physical activity in adults with XLH

Restrictions in range of motion and gait disturbances are common in adults with XLH, limiting their physical mobility. Many also suffer from pain and some adults may require the use of a walking device.2


1. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). American College of Rheumatology Website. Accessed March 1, 2018. 2. Skrinar A, Dvorak-Ewell M, Evins A, et al. The lifelong impact of X-linked hypophosphataemia: results from a burden of disease survey. J Endocr Soc. 2019;3(7):1321-1334.